Both belong to a new type of medication, called PCSK9 inhibitors, that work differently than statins. Muscle-related side effects were reported in 20.7% of Repatha patients and 28.8% of ezetimibe patients. For years, statins have been the drug of choice when it comes to treating high cholesterol, and that remains the case today. But a small percentage of people don’t do well with statins, meaning the drugs just aren’t enough, or sometimes, they cause side effects that are too bothersome. Heart experts had high expectations for Repatha, and a related drug called alirocumab (Praluent). “Statin-associated muscle symptoms represent a major unresolved challenge in the care of patients … In my case, after completely going off statins as instructed by my cardiologist, I … You are fortunate to be among those that can get the benefit of repatha without needing to take the statins. There are other medications on the market to help treat high cholesterol … Repatha, when added to statin therapy, reduced the percentage of patients requiring revascularization (7.2% vs. 9.3%, respectively), including new PCI, PCI for de novo lesions, PCI for not … The FDA has approved two of these drugs: alirocumab (Praluent) and evolocumab (Repatha).

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