Never give it to anyone else, even if their condition appears to be the same, as this could do harm. Powder: 454 g They will decide what to do based on your child’s condition and the specific medicine involved. You may not see an obvious difference but your child should start to feel better as the amount of ammonia in their body falls. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. It has a role as an antimicrobial food preservative, a drug allergen, an EC 1.13.11.33 ( arachidonate 15-lipoxygenase) inhibitor, an EC 3.1.1.3 (triacylglycerol lipase) inhibitor, an algal metabolite, a human xenobiotic metabolite and a plant metabolite. This leaflet is about the use of sodium benzoate for urea cycle disorders. What is sodium benzoate available as? WC1X 8SH. Multi-ingredient medications containing sodium benzoate: caffeine/sodium benzoate systemic. Just give the next dose as usual. All the above products have to be ordered specially by your pharmacist. Your child should not chew the tablet. Your doctor will work out the amount of sodium benzoate (the dose) that is right for your child. Make sure that the medicine you have at home has not reached the ‘best before’ or ‘use by’ date on the packaging. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. • Acidemia: Use with caution in patients with propionic or methylmalonic acidemia (Kliegman 2016). Do not use a kitchen teaspoon as it will not give the right amount. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Plasma ammonia, plasma amino acid (quantitative) and glutamine concentrations, blood glucose, serum electrolytes, hepatic and renal function tests, blood gases, neurologic status, physical signs/symptoms of hyperammonemia (ie, lethargy, ataxia, confusion, vomiting, seizures, and memory impairment) (Häberle 2012; Lichter-Konecki 2016). It is important that you follow your doctor’s instructions about how much to give. yoghurt or feed) or a small drink of water or milk. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Your child needs to take sodium benzoate regularly to help reduce the levels of ammonia in their body. Liquid medicine: Measure out the right amount using an oral syringe or medicine spoon. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. London For details on any other sources used for this leaflet, please contact us through our website, www.medicinesforchildren.org.uk. Capsules should be swallowed with a glass of water, milk or juice. Your child needs to take sodium benzoate regularly to help reduce the levels of ammonia in their body. The Royal College of Paediatrics and Child Health (RCPCH), the Neonatal and Paediatric Pharmacists Group (NPPG), WellChild and the contributors and editors cannot be held responsible for the accuracy of information, omissions of information, or any actions that may be taken as a consequence of reading this leaflet. If you are not sure a medicine is working, contact your doctor but continue to give the medicine as usual in the meantime. You are unlikely to do harm if you give an extra dose of sodium benzoate by mistake. We comply with the HONcode standard for trustworthy health information -, Urea Cycle Disorder (UCD) Treatment Agent. If you think someone else may have taken the medicine by accident, contact your doctor. Urea cycle disorders are inherited disorders where ammonia is not turned into uric acid properly and so it builds up in the blood. Sodium benzoate is an organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion. IV dosing is usually required for acute episodes; if IV administration is necessary, see the Sodium Phenylacetate and Sodium Benzoate monograph for information about a commercially available parenteral product. Maternal treatment with oral sodium benzoate is recommended if serum ammonia is 1.5 to 2 times normal (Mendez-Figueroa 2010). Your child’s doctor, pharmacist or nurse will be able to give you more information about sodium benzoate and about other medicines used to treat urea cycle disorders. If there is too much amino acid in the blood, it is turned to ammonia in the liver, and then into uric acid, which the body gets rid of in urine (wee). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Give old medicines to your pharmacist to dispose of. Monitor therapy. It is important that you ask the advice of your doctor or pharmacist if you are not sure about something. In general, females with inherited metabolic disease should achieve adequate metabolic control prior to conception (Häberle 2012; Langendonk 2012). Make sure that children cannot see or reach the medicine. Do not use acidic or fizzy drinks such as fruit juice or lemonade. Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more. Keep the medicine in a cupboard, away from heat and direct sunlight. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Administration of sodium benzoate to the mother to prevent adverse events in newborns prenatally diagnosed with a UCD has also been described (Das 2009). Ideally, give sodium benzoate to your child after a meal, some food or milk, as it is less likely to upset their stomach. You can report any suspected side-effects to a UK safety scheme at http://www.mhra.gov.uk/yellowcard. © NPPG, RCPCH and WellChild 2011, all rights reserved. Tablets: 500 mg; Capsules: 50 mg, 250 mg, 400 mg, 500 mg; Liquid medicine: 500 mg in 5 mL, 1 g in 5 mL, 1.5 g in 5 mL; Powder; All the above products have to be ordered specially by your pharmacist. Encourage them to eat small meals often. Make sure that you always have enough medicine. Keep it somewhere safe so that you can read it again. The primary source for the information in this leaflet is the British National Formulary for Children. The liquid can be mixed with a fruit drink, feed or milk. Have the medicine or packaging with you if you telephone for advice. We take great care to make sure that the information in this leaflet is correct and up-to-date. Urea cycle disorders, long-term therapy: Very limited data available: Dosage should be individualized based on patient response; consult metabolic specialist: Infants, Children, and Adolescents: Oral: 250 to 500 mg/kg/day in 3 to 4 divided doses given with meals (Häberle 2012; Kliegman 2016, Maestri 1991; Maestri 1996). Try to give medicines at about the same times each day,  to help you remember. Wait until the next normal dose. If your child is sick more than 30 minutes after having a dose of sodium benzoate, you do not need to give them another dose. Your child should not chew the tablet. Information related to the use of sodium benzoate for urea cycle disorders (UCD), including ornithine transcarbamylase (OTC) deficiency, during pregnancy is limited (Häberle 2012; Lamb 2013; Mendez-Figueroa 2010). If you are concerned that you may have given your child too much, contact your doctor or local NHS services (111 in parts of England; 0845 4647 in parts of England and Wales; 08454 24 24 24 in Scotland). Your child should then swallow the food or drink straight away, without chewing. We use medicines to make our children better, but sometimes they have other effects that we don’t want (side-effects). If you notice anything unusual and are concerned, contact your doctor. Keep the medicine in the container it came in. Benzoate can be detected in the umbilical cord and newborn serum following maternal administration of sodium benzoate prior to delivery (Das 2009). Note: Sodium benzoate is not commercially available as a ready-to-use product; however, some centers are still using compounded formulations when necessary. Your child may feel sick (nausea) or be sick (vomit) when they first start to take sodium benzoate. Specifically, probenecid may inhibit the renal transport of the hippuric acid metabolite of sodium benzoate. 5-11 Theobalds Road Frequency not defined. Medicines for Children The dose will be shown on the medicine label. Only give this medicine to your child. Avoid giving it on an empty stomach. However, medicines can be used in different ways for different patients. The following side-effects should decrease with time; if you are worried, or any of them are still a problem after one week, contact your doctor, but continue to give sodium benzoate: There may, sometimes, be other side-effects that are not listed above. If your child is sick again, seek advice from your GP, pharmacist or hospital. Additionally, more concentrated levels of sodium benzoate may be prescribed if … Please read this leaflet carefully. The information may differ from that provided by the manufacturer. You can get these from your pharmacist.

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