Health Benefits. Chem. Res. Kaempferol is a natural flavonol which is a natural flavonol or flavonoid found in various plants and plant derived foods. In another study with kaempferol, it was possible to note the antiinflammatory action via modulation iNOS and COX-2 by the NF-kB pathway, also the inhibition of COX-1 production [103,104]. Furthermore, it acts as a phytoestrogen, which regulates estrogen levels in the body. In 2010, Park et al. Saving You Time. In the research of kaempferol, it was discovered that rats treated with the flavonol exhibited significantly higher bone mineral density in the trabecular regions — femur neck, proximal tibia, and vertebrae — and lowered serum ALP.

(Phila) 2014;7:958-67; Biochem.

Bull. Kaempferol is one of the many flavonoids found in foods alongside others like luteolin and quercetin. 1.

Study shows that kaempferol acts as chemopreventive agent that inhibits cancer cells formation. Aside from its cancer-fighting properties, kaempferol acts as an antioxidant and protects the body from damaging free radicals, which are harmful by-products of oxygen-based reactions. It possesses antioxidant properties that help to lower oxidative stress. This indicated that the plant’s leaf extracts have a potential for cancer chemopreventation and can be claimed as a therapeutic agent against cancer. Work by Kim et al.

Venereol. In the investigation of the effects of kaempferol -3,7-O- (alpha)-dirhamnoside (kaempferitrin) on serum glucose levels for its antioxidant potential and hypoglycemic effect found that the hypoglycemic effect of kaempferitrin in diabetic rats was evident at all doses tested (50, 100, and 200 mg/kg), and this profile was maintained throughout … They concluded that kaempferol exerts robust chemopreventive activity against skin cancer by suppressing Src (Biochem. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners. Bull. 2008;40:208-19), and is believed to play a role in protecting plants from ultraviolet (UV)-induced damage (J. Agric. Discovered in 1938 by Albert Szent-Györgyi, a Hungarian biochemist, it is known to be a strong antioxidant and can help prevent oxidative damage of the body’s cells, lipids, and the deoxyribonucleic acid (DNA). Kaempferol also hindered p38 mitogen-activated protein kinase c-Jun N-terminal kinase (JNK) activation. found that kaempferol acted as a safe and potent inhibitor of solar ultraviolet-induced mouse skin carcinogenesis that acted by targeting RSK2 and MSK1 ( Cancer Prev. Pharmacol. Hypoglycemic and antioxidant effects. These components may result in anti-inflammatory and anti-aging effects. stem bark extracts. recently showed that submicron emulsions are effective carriers for the transdermal delivery of kaempferol (Chem.

Kim and colleagues have also shown in animal studies that the topical application of P. persica may be effective at thwarting UVB-induced skin damage (J. Cosmet.

It is not intended as a substitute for professional advice of any kind. Lee et al. Benefits to the skin include: Anti-inflammatory and anti-aging effects. It is a yellow crystalline solid having melting point of 276–278 °C (529–532 °F). Intake of kaemferol helps to lower chances of cancers and possible for treating cancer. 2010;49:276-82). They concluded that kaempferol exerts robust chemopreventive activity against skin cancer by suppressing Src (Biochem. 2013 June 27 [doi:10.1111/jdv.12204, Manage Your Dermatology Practice: Managing Difficult Patient Encounters, Expert Insights in Hidradenitis Suppurativa, Treating Patients with Acne by Telemedicine in the Era of COVID-19, Nurse Practitioners / Physician Assistants. In addition, kaempferol is a key component in Punica granatum, which has been found to act as an effective protector against UVB-induced photodamage and aging in cultured skin fibroblasts (Int. See more with MDedge! They concluded that their findings suggest the possible application of kaempferol to treat thermal burn–induced skin injuries (BMB Rep. 2010;43:46-51). It also lessens the risk of cardiovascular diseases. 2012;60:6966-76). Significantly, in terms of topical delivery, Chao et al. MDedge: Keeping You Informed.

Kaempferol is a flavonoid that acts as an antioxidant. Health Benefits of Kaempferol Kaempferol is a strong antioxidant which helps to prevent oxidative damage of cells, DNA and lipids.

Truth Publishing assumes no responsibility for the use or misuse of this material. Pharm. demonstrated that kaempferol alleviated burn injuries in mice and that expression of tumor necrosis factor–alpha (TNF-alpha) induced by burn injuries was reduced by kaempferol. 2010;80:2042-9). Food Chem. Guidance from the experts in 2002 revealed that four kaempferol glycosides are key active ingredients in the flowers of Prunus persica, which has long been used in traditional Chinese medicine to treat skin disorders (J. Cosmet. Like quercetin, kaempferol is an exciting polyphenolic compound that you should be watching for new health-related research. A study found that through alterations in lipoprotein metabolism, oxidative stress, and inflammatory markers, intake of the nutrient beneficially affected key risk factors of coronary heart disease in both pre- and postmenopausal women. Skin protection: antioxidant and anti-inflammatory activity. http://www.phytochemicals.info/phytochemicals/kaempferol.php, Linolelaidic acid is an omega-6 trans fatty acid and a geometric isomer of linoleic acid.…, Fiber isn’t a single nutrient but a family of plant-based nutrients that are generally resistant…, Niacin is more commonly recognized as vitamin B3 and is part of the B-complex vitamins.…, Flavonoids constitute a large class of phytochemicals that are widely distributed in the plant kingdom,…, Lutein and Zeaxanthin facts and food sources, Vitamin K2 food sources and health benefits, Facts and Food Sources of Linolelaidic acid. It also helps support heart and brain health. 2010;80:2042-9 ). It is also known to prevent arteriosclerosis, heart disease, and osteoporosis. Kaempferol is a strong antioxidant which helps to prevent oxidative damage of cells, DNA and lipids. Dermatol. Kaempferol was found to be good for people who suffer from osteoporosis. Food Chem. Significantly, kaempferol is known to exhibit anticancer, anti-inflammatory, antioxidant, cytoprotective, and antiapoptotic activity (Cancer Prev. Another study found that kaempferol, together with other flavonoids such as apigenin and luteolin, has analgesic and anti-inflammatory effects contained in the Cassia siamea Lam.

Administration of kaempferol might be an alternative treatment for skin fibrosis in SSc.

2010;80:2042-9; Exp. Sci. Venereol. Res. Do you have information you’d like to share on kaempferol?

Sci. Pharm.

Ginkgo leaf extract contains quercetin and kaempferol, natural plant flavonoids that act as antioxidants, and help fight free radicals. 2002;53:27-34). In a study, it was found out that flavonols quercetin and kaempferol significantly increased alkaline phosphate (ALP) activity which then can stimulate osteoblastic activity. in 2011 to be associated with kaempferol and kaempferol rhamnosides isolated from Hibiscus cannabinus (Molecules 2011;16:3338-44). Kaempferol is becoming an exciting nutritional compound with promise for reducing the risks of developing certain types of cancer and inflammatory-based diseases.



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