0001083069 00000 n 0000125902 00000 n This finding was statistically significant at the low-dose level but not at the high-dose level. 0000120259 00000 n 0000120723 00000 n 6. 133 0 obj<>stream If you originally registered with a username please use that to sign in. 0000566008 00000 n This website uses cookies to ensure you get the best experience on our websites. 0000263268 00000 n 0000184190 00000 n 4, Taipei, Taiwan, Department of Plant Protection, Chiayi Agricultural Experiment Station, Taiwan Agricultural Research Institute, Chiayi, Taiwan. 0000003285 00000 n In its review of eugenol, JECFA (2006b) discussed the hepatic findings in the mouse study and noted not only the sensitivity of the mouse strain, but also the potential effect of other factors such as housing of the animals. 0000870428 00000 n In the key mouse (B6C3F1 strain) study, dietary administration of eugenol at concentrations of 0 (control), 3,000, or 6,000 ppm did not result in any test article-related changes in mean body weights, mean food consumption, and survival in either males or females (NTP, 1983).
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0000003226 00000 n 0000656541 00000 n 0000119055 00000 n In this study, mark-recapture experiments were used to analyze the effects of naled-intoxicated ME on field and naled-resistant fly strains. This article is also available for rental through DeepDyve. 0000916349 00000 n 0000812954 00000 n 1990;245:23-26. The key and several reliable in vitro and in vivo genotoxicity studies all provide negative result for mutagenicity and clastogenicity. 0001008911 00000 n In female mice, the incidence of hepatocellular adenomas and carcinomas (combined) was statistically significant only at the high-dose; although a dose-response trend was seen, the incidences of adenomas or carcinomas alone were not statistically significant at either dose. Phillips DH, Reddy MV, Randerath K. (32)P-Post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally- occurring alkenylbenzenes. 0000520230 00000 n Carcinogenesis 1984;5:1623-1628. endstream endobj 9 0 obj<> endobj 10 0 obj<>/ArtBox[0.0 0.0 612.0 792.0]/MediaBox[0.0 0.0 612.0 792.0]/Thumb 3 0 R/TrimBox[0.0 0.0 612.0 792.0]/Resources<>/ColorSpace<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>>>/ExtGState<>>>/Type/Page/LastModified(D:20110110093922-07'00')>> endobj 11 0 obj<> endobj 12 0 obj<> endobj 13 0 obj<> endobj 14 0 obj<> endobj 15 0 obj[/Separation/All/DeviceCMYK<>] endobj 16 0 obj<>stream : World Health Organization (WHO), International Programme on Chemical Safety (IPCS); 2006b:155-200. %%EOF 0000004687 00000 n

0000963325 00000 n

0000263639 00000 n This conclusion is consistent with that of the recent review of the toxicology of eugenol conducted by the European Food Safety Authority, which concluded that eugenol is devoid of carcinogenic activity (EFSA, 2009). Based on the data, the evidence indicates that eugenol is not a carcinogen in rodents. 0000543564 00000 n 0000125858 00000 n Statistically significant increases were not noted in the low-concentration (i.e., 3,000 ppm) group. 0000019517 00000 n Table 1          Historical Liver Tumour Incidences in B6C3F1 Mice Compared to Liver Tumour Incidences From a 103-Week Study in B6C3F1 Mice, (%) Tumour Incidences from NTP (1983) Study for Eugenol; 3,000 ppm, (%) Tumour Incidences from NTP (1983) Study for Eugenol; 6,000 ppm, Historical control ranges are based on NTP carcinogenesis studies in, Values for males of the low-concentration (, Statistically significant increases were not noted in the high-concentration (, Values for females of the high-concentration (, Statistically significant increases were not noted in the low-concentration (, In the supporting mouse (CD-1 strain) study designed specifically to investigate the development of hepatomas, administration of 0.5% eugenol in the diet (with or without 0.05% phenobarbital in the drinking water) for 20 months did not result in the development of hepatic tumours (Miller. 0000184212 00000 n 0000324256 00000 n 0000300509 00000 n

0000120767 00000 n 0000015319 00000 n aHistorical control ranges are based on NTP carcinogenesis studies in untreated B6C3F1 mice. 0000118705 00000 n You could not be signed in. 0000116651 00000 n

0000853872 00000 n Active Ingredients: Methyl Eugenol (4-Allyl-1,2-Didmethoxybenzene).....76.9% Other Ingredients.....33.1% Total.....100.00% CAUTION KEEP OUT OF REACH OF CHILDREN PRECAUTIONARY … Naled-intoxicated methyl eugenol (ME) is commonly used to control oriental fruit flies, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), in Taiwan. 0000010146 00000 n Particle size distribution (Granulometry), Solubility in organic solvents / fat solubility, Stability in organic solvents and identity of relevant degradation products, Storage stability and reactivity towards container material, Biodegradation in water and sediment: simulation tests, Additional information on environmental fate and behaviour, Short-term toxicity to aquatic invertebrates, Long-term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disrupter testing in aquatic vertebrates – in vivo, Toxicity to soil macroorganisms except arthropods, Endocrine disrupter mammalian screening – in vivo (level 3), Direct observations: clinical cases, poisoning incidents and other, Exposure related observations in humans: other data, Justification for classification or non-classification, Additional physico-chemical properties of nanomaterials, Toxicokinetics, metabolism and distribution.

The carcinogenic potential of eugenol was investigated in 2 key studies in mice and rats (NTP, 1983) and a supporting study in mice (Miller. 0000833821 00000 n Geneva, Switz. 0000006610 00000 n 0000115373 00000 n 0000631316 00000 n This site is not fully supported in Internet Explorer 7 (and earlier versions).

A statistically significant increase in hepatocellular tumours in male mice at the low-dose level, but not at the mid- and high-dose level, indicating a lack of a dose-response relationship; 3. Therefore, on the basis of scientific considerations eugenol is concluded not to be carcinogenic in mice or rats, based on the following: 1. 0001063562 00000 n Sixty-Fifth Report of the Joint FAO/WHO Expert Committee on Food Additives, June 7-16, 2005.

Department of Entomology, National Taiwan University, No.

Thompson DC, Constantin-Teodosiu D, Moldeus P. Metabolism and cytotoxicity of eugenol in isolated rat hepatocytes. 0000000016 00000 n This finding was statistically significant at the low-dose level but not at the high-dose level. In the key rat (F344/N strain) study, dietary administration of eugenol at concentrations of 0 (control), 3,000, or 6,000 ppm to males and 0 (control), 6,000, or 12,500 ppm to females for 104 weeks did not result in any test article-related changes in mean body weight, mean food consumption, or survival. This conclusion is consistent with that of the recent review of the toxicology of eugenol conducted by the European Food Safety Authority, which concluded that eugenol is devoid of carcinogenic activity (EFSA, 2009). For full access to this pdf, sign in to an existing account, or purchase an annual subscription. For permissions, please e-mail: journals.permissions@oup.com.

0000230920 00000 n 0000231187 00000 n

0000938995 00000 n In: Safety Evaluation of Certain Food Additives: Sixty-fifth Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). In 1988, CDFA's Environmental Hazards Assessment Program (EHAP) conducted a study to determine the concentrations of methyl eugenol, naled and DDVP in ambient air and fruit .during oriental fruit fly trapping and eradication programs. chemical exposure levels during such programs.
Haseman JK, Hailey JR, Morris RW. Don't already have an Oxford Academic account? Finally, the effects of fipronil-intoxicated ME were analyzed to determine whether control efficiency could be enhanced through the use of alternate pesticides. The 1'-hydroxy metabolite is considered to be the proximate carcinogen.

0000183053 00000 n Neoplasms observed in untreated and corn oil gavage control groups of F344/N rats and (C56BL/6N X C3H/HeN)F(1) (B6C3F1) mice. As a result, the substance does not meet the criteria for classification according to Regulation (EC) No 1272/2008, Annex I section 3.6. 0000125407 00000 n 0000004129 00000 n 0000119034 00000 n Eugenol and related hydroxyallylbenzne derivatives\. 0000183550 00000 n 0000015449 00000 n JECFA concluded that the hepatic neoplasms in the NTP study are "not relevant to the safety of eugenol in humans". 0000264256 00000 n 451 and none of the studies were conducted according to Good Laboratory Practices (GLP). 0000264144 00000 n Table 1          Historical Liver Tumour Incidences in B6C3F1 Mice Compared to Liver Tumour Incidences From a 103-Week Study in B6C3F1 Micea, (%) Tumour Incidences from NTP (1983) Study for Eugenol; 3,000 ppmb, (%) Tumour Incidences from NTP (1983) Study for Eugenol; 6,000 ppmc.

0000121110 00000 n 0000756399 00000 n In addition, there was no evidence of carcinogenicity in either male or female rats compared to controls (NTP, 1983). Methyl eugenol has been shown to be metabolised by allylic 1'-hydroxylation followed by sulphation leading to an unstable genotoxic metabolite. H��W]�d7���s�=�m�,�5I Oi�Ca�lv7a���W�,���������'^ޟ��o?O�p�p��Ib���7k4�?-��s>L��!-��9|;�z �Q��傡HT|�L�;�}� ��x�I! J Natl Cancer Inst 1985;75:975-984. x�b``�f`�f``��a@,`������d22�Og k`�+ad�d�i�[�v���ɀ�C1Ӄ���,w0e~������'���$0 M�J Net contents: 250 Methyl Eugenol Cones/Case: 2500 grams The Scentry Methyl Eugenol Coneis a semiochemical insect attractant for control of the oriental fruit fly (Bactrocera dorsalis).. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. 0000125882 00000 n %PDF-1.4 %���� 0000017478 00000 n 0000474736 00000 n 56). Evidence from in vivo studies in mice that eugenol does not bind to DNA (no formation of hepatocellular DNA adducts)(Phillips et al.,1984; Phillips, 1990), likely due to the presence of detoxification processes and/or mechanisms (i.e., glutathione conjugation), as exemplified in the report of Thompson et al. 0000775208 00000 n 0000004266 00000 n `�'���WGp s��-�G�q�W`��[���$1#��I���. Consequently, methyl eugenol is not a valid analogue of eugenol. However, non-responsiveness to ME and pesticide resistance in oriental fruit flies may reduce control efficacy.


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